Oxidative stress and sging: role of physical exercise
DOI:
https://doi.org/10.5016/1980-6574.2010v16n2p506Keywords:
Espécies reativas de oxigênio. Exercício físico. IdosoAbstract
Different theories have been developed to explain the aging process and the Free-radical Theory of Aging had shown significant evidence that aging is the result of ROS toxicity action that lead to cellular DNA injury, lipid and protein oxidation. While during exercise session a major oxygen consumption increases ROS production, an adaptation occurs at cellular level and antioxidant enzymes concentration or activity are increase. Therefore, this review aims to show the mainly mechanisms of ROS generation and antioxidant defense mechanisms, as well the adaptations induced by physical exercise that act as a protection against oxidative stress related-injuries.Downloads
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