Skeletal muscle, chronic heart failure and the role of the exercise.
DOI:
https://doi.org/10.5016/2079Keywords:
Insuficiência Cardíaca Crônica. Músculo Esquelético. Exercício Físico. Terapias.Abstract
Patients with chronic heart failure (CHF) show metabolic, hemodynamic and skeletal muscle alterations which decrease the life expectancy and are attributed to several factors. The focus of this review it will be on the questions related to physiological, metabolic, morphological and molecular alterations which affect the muscular system of these patients. Later, it will be discussed how the physical exercise contributes to this syndrome as well as the pharmacological interventions which are in investigation aiming the treatment of the same. Some muscle alterations are already described on the literature. For example, the more predominance of type II fibers, lower oxidative enzymatic activity, muscle atrophy and elevated concentration of cytokines that affect the muscle integrity. Thus, further studies involving cellular and molecular mechanisms of skeletal muscle in order to create strategies for prevention and treatment for patients with CHF are required.Downloads
Published
Issue
Section
License
Authors who publish in this journal agree to the following terms:
a) The authors assign copyright to the magazine, with the work simultaneously licensed under the Creative Commons Attribution License, which allows the work to be shared with recognition of its authorship and publication in this magazine.
b) The policy adopted by the Editorial Committee is to assign copyright only after a period of 30 months from the date of publication of the article. After this time, authors interested in publishing the same text in another work must send a letter to the Editorial Committee requesting permission to transfer copyright and await a response.
c) This magazine provides public access to all its content, as this allows greater visibility and reach of published articles and reviews. For more information about this approach, visit the Public Knowledge Project, a project that developed this system to improve the academic and public quality of research, distributing OJS as well as other software to support the public access publishing system for academic sources. The names and email addresses on this site will be used exclusively for the purposes of the magazine and will not be available for other purposes. This journal provides open any other party This work is licensed under a Creative Commons License