Apoptosis and sarcopenia of skeletal muscle at aging

Authors

  • Fabrício Azevedo Voltarelli Depatramento de Educação Física-UNESP Rio Claro, SP, Brasil
  • Maria Alice Rostom de Mello Departamento de Educação Física Unesp-Rio Claro, SP, Brasil
  • José Alberto Ramos Duarte Laboratório de Bioquímica do Exercício - Faculdade do Desporto da Universidade do Porto, Portugal

DOI:

https://doi.org/10.5016/758

Keywords:

Envelhecimento. Sarcopenia. Músculo esquelético. Apoptose. Mitocôndria.

Abstract

Although the exact mechanisms underlying sarcopenia are far to be unveiled, accumulating preclinical evidence suggests that an age-related acceleration of myocites loss via apoptosis might represent a key mechanism driving the onset and progression of muscle loss. Furthermore, increased levels of apoptosis have also been reported in old rats undergoing acute muscle atrophy subsequent to muscle unloading. Several signaling pathways of skeletal muscle apoptosis are currently under intensive investigation, with a particular focus on the role played by mitochondria. Here, we will review the most recent evidence regarding various pathways of muscle apoptosis and their modulation by several interventions.

Author Biographies

Fabrício Azevedo Voltarelli, Depatramento de Educação Física-UNESP Rio Claro, SP, Brasil

Departamento de Educação Física no Laboratório de Biodinâmica da Unesp-Rio Claro, SP, Brasil. Tem experiência na área de Nutrição Geral e Esportiva, Fisiologia Geral, Fisiologia do Exercício e Fisiologia Endócrino-Metabólica, atuando principalmente nos seguintes temas: ratos Wistar, natação, exercício de força, desnutrição protéico-calórica, alimentação do atleta, lactato mínimo, transição metabólica (aeróbio/anaeróbio), desnutrição associada ao exercício físico e recuperação nutricional e apoptose. http://lattes.cnpq.br/8710187484419682

Maria Alice Rostom de Mello, Departamento de Educação Física Unesp-Rio Claro, SP, Brasil

Professor adjunto Departamento de Educação Física Unesp-Rio Claro, SP, Brasil. Linha de pesquisa principal: Fisiologia endócrino-metabólica e exercício, que visa o estudo de adaptações ao exercício em modelos animais de diferentes condições fisiológicas e patológicas. http://lattes.cnpq.br/0332111504399487

José Alberto Ramos Duarte, Laboratório de Bioquímica do Exercício - Faculdade do Desporto da Universidade do Porto, Portugal

Docente da Faculdade do Desporto da Universidade do Porto, Portugal

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Published

2007-10-23

Issue

V. 13, N. 2 (2007)

Section

Review Articles

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